It is a rare chance to see the Italian champions face off against a major club and a top flight side in Europe.
It’s a game they should be looking to win and to win comfortably.
The game kicks off at 2.00pm (local time) on Saturday and will be broadcast live on Fox Sports.
Juventus have won five out of their six league games in all competitions this season and it will be an interesting match to see if they can keep up their current form.
They are unbeaten in their last five Serie A games and are in form at the top of the table, winning six of their last seven games.
They have a tough task in hand with Inter in fourth, and they should win this match to avoid the worst of the four-match suspension.
Juve had to settle for a draw against Napoli in the Europa League last weekend, and there was a sense they were just waiting for their chance to take the lead.
The Nerazzurri are in the midst of a poor run of form that has seen them fall to sixth, just one point behind the top two.
This is a game Juve should be happy to take advantage of, and if they get the win they could see the rest of the league tumble into the abyss.
Juventas last league win came in December, when they defeated Roma 2-0, but they are still unbeaten in nine Serie A fixtures, which is good enough for third in the table.
They are currently third in Serie B, but it’s a tricky position for them, as they have a difficult run of fixtures ahead, with a tough trip to Inter to look forward to in the coming weeks.
If they can hold off the hosts, Juventus should have no problem keeping up with the leaders and taking a point from the game, but Inter will be without the suspended Dani Alves and Paulo Dybala.